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commit d8c5215c5dbe0b624f14b5990e174e4fac1e126e
parent 3481acdab966cb25175c946d3e3cb3466b67e169
Author: Beau Hilton <beau.hilton@vumc.org>
Date:   Sun, 22 Aug 2021 15:00:32 -0500

TLS criteria

Diffstat:
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posts/mr-2021.md
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19
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1 file changed, 18 insertions(+), 1 deletion(-)
diff --git a/posts/mr-2021.md b/posts/mr-2021.md
@@ -92,7 +92,24 @@ Details modified, generalized, and otherwise fudged to be HIPAA-compliant.
 
 [![TLS](https://cdn.jamanetwork.com/ama/content_public/journal/oncology/937239/cpg180002fa.png?Expires=1632594426&Signature=y4M-w5gXSYJCAVMqGVEyfaPaqZocE9nGaWFnmr7GY7vuiD35l7dL-yJLWn4l3huTo4yBhri1nM0KjQ4dZBBjEYH5tPmKExEJ0D6V~WNou9Av-OEwhyQh79y9feHp790YWY6hTKRJJge958meDu~OmNl8Sl0Wn1N4buZZgVNMRdRds9fKbaDr4DhEdCbMgFbbLSeW9h8KIOm49Gog8FREQNntRaN1jILZgKPBTr9sUNv2BUiapZaLPO4teIf33LkJXcStx6o1VVsZJoP-G-sfMKG3ql1O~23E6LFJeirnMt5MYQdfk-LZlieuSw16HzqTXr-jBtOicDtyFzDJ9VcQ~g__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA =500x500 'JAMA Oncology 2018, TLS Review')](https://jamanetwork.com/journals/jamaoncology/fullarticle/2680750)
 
-- laboratory vs clinical
+### Laboratory TLS
+
+
+| Metabolite/Electrolyte  | Criterion                                |
+| ----------------------- | ---------------------------------------- |
+| Uric Acid               | >=8 mg/dL or 25% increase from baseline  |
+| Potassium               | >=6mEq/L or 25% increase from baseline   |
+| Phosphorus              | >=4.5mg/dL or 25% increase from baseline |
+| Calcium                 | 25% *decrease* from baseline             |
+
+
+### Clinical TLS
+
+- Laboratory TLS and one or more of:
+  - creatinine >= 1.5 ULN
+  - cardiac arrhythmia or sudden death
+  - seizure
+
 - risk assessment
 - rasburicase
 - allopurinol